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If you recently titrated up to a higher dose and your constipation dramatically worsened, that dose increase is likely the primary driver

Recommendation tiers: (i) Strongly Recommended: GLP-1RAs may be used as time-bounded metabolic optimization before OI or ART, aiming to improve metabolic readiness prior to stimulation and pregnancy planning

The main difference between the natural GLP-1 and the medication is the synthetic hormone lasts considerably longer than the naturally occurring hormone- around 7 days

Moderate coffee consumption actually has a mild prokinetic effect, meaning it stimulates colonic contractions